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Top/HDAC-IN-2

Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].

Product Specifications

CAS Number

2775446-64-3

UNSPSC

12352005

Target

Apoptosis; HDAC; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/top-hdac-in-2.html

Solubility

10 mM in DMSO

Smiles

CN1C2=C(C(N3CCC4=C(C13)NC5=CC=C(C=C54)O)=O)C=C(C=C2)NCC6CCN(CC6)C7=NC=C(C=N7)C(NO)=O

Molecular Formula

C30H32N8O4

Molecular Weight

568.63

References & Citations

[1]Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top) /Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; Topo I; Topo II

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