VEGFR2-IN-1

VEGFR2-IN-1 is a potent and selective VEGFR2 inhibitor (IC50=19.8 nM) . VEGFR2-IN-1 inhibits cell proliferation and migration through apoptosis activation and VEGFR2 inhibition[1].

Product Specifications

CAS Number

[2765224-55-1]

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr2-in-1.html

Solubility

10 mM in DMSO

Smiles

C=CCSC1=NN=C(N1/N=C/C2=CNC3=CC=CC=C23)C4=CC5=CC=CC=C5N4

Molecular Formula

C22H18N6S

Molecular Weight

398.48

References & Citations

[1]Nafie MS, Boraei ATA. Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer. Bioorg Chem. 2022; 122:105708.