HDAC1/MAO-B-IN-1

HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1]. HDAC1/MAO-B-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2759855-37-1]

UNSPSC

12352005

Target

HDAC; Monoamine Oxidase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hdac1-mao-b-in-1.html

Solubility

10 mM in DMSO

Smiles

C#CCN(CC1=CC(Cl)=CC=C1)CC2=CC=C(C=C2)C(NO)=O

Molecular Formula

C18H17ClN2O2

Molecular Weight

328.79

References & Citations

[1]Yao C, et al. HDAC1/MAO-B dual inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. Bioorg Chem. 2022; 122:105724.