AAK1-IN-5
AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM) . AAK1-IN-4 has the potential for the research for neuropathic pain[1].
Product Specifications
CAS Number
1815613-44-5
UNSPSC
12352005
Target
AAK1
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aak1-in-5.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@](N)(COC1=CN=C(C2=CC=NC(C(F)F)=C2)C=C1C(F)F)C)C
Molecular Formula
C19H23F4N3O
Molecular Weight
385.40
References & Citations
[1]Luo G, et al. Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. J Med Chem. 2022;65 (6) :4534-4564.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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