(S) -PERK-IN-5

(S) -PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S) -PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2].

Product Specifications

CAS Number

[2616821-92-0]

UNSPSC

12352005

Target

PERK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/s-perk-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(C2=CC=C(NC([C@H](C3=CC(F)=CC(F)=C3)O)=O)C=C2CC)=CN=C1N)NC(C)C

Molecular Formula

C25H26F2N4O3

Molecular Weight

468.50

References & Citations

[1]Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.|[2]Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1.