sEH/AChE-IN-4
Product Specifications
UNSPSC Description
sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Target Antigen
Cholinesterase (ChE); Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seh-ache-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
Molecular Weight
670.16
References & Citations
[1]Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145833A/sEH-AChE-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145833A/
Clinical Information
No Development Reported
CAS Number
2490589-12-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![PARP7, NT (TCDD-inducible Poly [ADP-ribose] Polymerase, Poly [ADP-ribose] Polymerase 7, PARP-7, TIPARP) (FITC)](https://cdn.genprice.uk/genprice/genprice5.png)
MBS6492184-01 0.2 mL
PARP7, NT (TCDD-inducible Poly [ADP-ribose] Polymerase, Poly [ADP-ribose] Polymerase 7, PARP-7, TIPARP) (FITC)
Ask
View Details ![PARP7, NT (TCDD-inducible Poly [ADP-ribose] Polymerase, Poly [ADP-ribose] Polymerase 7, PARP-7, TIPARP) (FITC)](https://cdn.genprice.uk/genprice/genprice2.png)
MBS6492184-02 5x 0.2 mL
PARP7, NT (TCDD-inducible Poly [ADP-ribose] Polymerase, Poly [ADP-ribose] Polymerase 7, PARP-7, TIPARP) (FITC)
Ask
View Details MBS6306339-01 0.2 mL
HHAT, NT (HHAT, MART2, SKI1, Protein-cysteine N-palmitoyltransferase HHAT, Hedgehog acyltransferase, Melanoma antigen recognized by T-cells 2, Skinny hedgehog protein 1) (PE)
Ask
View Details 
MBS6306339-02 5x 0.2 mL
HHAT, NT (HHAT, MART2, SKI1, Protein-cysteine N-palmitoyltransferase HHAT, Hedgehog acyltransferase, Melanoma antigen recognized by T-cells 2, Skinny hedgehog protein 1) (PE)
Ask
View Details 