SEH/AChE-IN-4
SEH/AChE-IN-4 (compound (+) -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Product Specifications
CAS Number
2490589-12-1
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seh-ache-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
Molecular Formula
C35H39ClF3N5O3
Molecular Weight
670.16
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Frequently Asked Questions
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