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EGFR-IN-43

EGFR-IN-43 (Compound 17c) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-43 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-43 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-43 has superior anti-cancer activity[1].

Product Specifications

CAS Number

3031307-74-8

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-43.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(NC2=C3C(C=C(OC)C(OCCCNC(CCCCCCN(CCOC4=CC=C(C=C4)/C(C5=CC=C(C=C5)O)=C(CC)\C6=CC=CC=C6)C)=O)=C3)=NC=N2)=CC=C1F

Molecular Formula

C50H55ClFN5O5

Molecular Weight

860.45

References & Citations

[1]Abdelmalek CM, et al. Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer. J Med Chem. 2022;65 (6) :4616-4632.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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