JPS035

JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC) . JPS035 degrades class I histone deacetylase (HDAC) . JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Product Specifications

CAS Number

2669785-84-4

UNSPSC

12352005

Target

HDAC; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jps035.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=C(C=C(C3=C(C)N=CS3)C=C2)OCCCCCCCCCCCC(NC4=CC=C(C=C4)C(NC5=C(C=CC=C5)N)=O)=O)=O)=O)=O

Molecular Formula

C49H65N7O7S

Molecular Weight

896.15

References & Citations

[1]Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65 (7) :5642-5659.