Difluorocyclooctyne-CH2-benzoic acid

Difluorocyclooctyne-CH2-benzoic acid is a Difluorinated cyclooctyne (DIFO) analogue that can be used for imaging glycans on live cells. Difluorinated cyclooctyne (DIFO) reagents rapidly reacts with azides in living cells without the need for copper catalysis[1]. Difluorocyclooctyne-CH2-benzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1047997-30-7]

UNSPSC

12352200

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/difluorocyclooctyne-ch2-benzoic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(CC2CCCCC#CC2(F)F)C=C1)O

Molecular Formula

C16H16F2O2

Molecular Weight

278.29

References & Citations

[1]Julian A Codelli, et al. Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc. 2008 Aug 27;130 (34) :11486-93.