HIgG-hFc receptor-IN-1

HIgG–hFc receptor-IN-1 (comp 66) is a human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein-protein interaction inhibitor, with an IC50 of 2 μM [1].

Product Specifications

CAS Number

[1425051-22-4]

UNSPSC

12352005

Target

Fc Receptor (FcR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/higg-hfc-receptor-in-1.html

Solubility

10 mM in DMSO

Smiles

N#CC(C1=NC2=C(N=C1N3CCCCCC3)C=CC=C2)C(NC(CN4CCOCC4)C5=CC=C(C=C5)OC)=O

Molecular Formula

C30H36N6O3

Molecular Weight

528.65

References & Citations

[1]Zhaolin Wang, et al. Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction. Bioorg Med Chem Lett. 2013 Mar 1;23 (5) :1253-6.