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PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-22 (Example 2) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-22 blocks PD-1/PD-L1 with the IC50 of 0.732 μM. PD-1/PD-L1-IN-22 can be used for the research of cancers, infectious diseases and autoimmune diseases[1].

Product Specifications

CAS Number

2159063-12-2

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-22.html

Solubility

10 mM in DMSO

Smiles

O=C(C)NCCNCC1=CC(Cl)=C(C=C1OC)OCC2=CC=CC(C3=CC=CC=C3)=C2Br

Molecular Formula

C25H26BrClN2O3

Molecular Weight

517.84

References & Citations

[1]Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof. WO2017202276A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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