PD-1/PD-L1-IN-18

PD-1/PD-L1-IN-18 (Compound L31) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-18 blocks PD-1/PD-L1 with the IC50 of 1.054 μM. Antitumor Activity[1].

Product Specifications

CAS Number

[2648851-27-6]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-18.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(OCC2=CC=CC(C3=CC=CC=C3)=C2Br)C=C(OCC4=CC5=NON=C5C=C4)C(CNC6CCC(CC6)O)=C1.Cl

Molecular Formula

C33H32BrCl2N3O4

Molecular Weight

685.43

References & Citations

[1]Liu Liu, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[ c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64 (12) :8391-8409.