PD-1/PD-L1-IN-18
Product Specifications
UNSPSC Description
PD-1/PD-L1-IN-18 (Compound L31) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-18 blocks PD-1/PD-L1 with the IC50 of 1.054 μM. Antitumor Activity[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-18.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(OCC2=CC=CC(C3=CC=CC=C3)=C2Br)C=C(OCC4=CC5=NON=C5C=C4)C(CNC6CCC(CC6)O)=C1.Cl
Molecular Weight
685.43
References & Citations
[1]Liu Liu, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[ c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145768/PD-1-PD-L1-IN-18-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145768/
Clinical Information
No Development Reported
CAS Number
2648851-27-6
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