GS-8873 (TFA)
GS-8873 TFA is the TFA salt form of GS-8873. GS-8873 TFA is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 TFA exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 TFA causes neurofunctional deficits in rats and cynomolgus monkeys[1][2].
Product Specifications
CAS Number
2241575-60-8
Product Name Alternative
HBV-IN-19 (TFA)
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-8873-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.COCC1=C(OCCCOC)C=C([C@]2([H])N(C(C)(CC2)C)N3C4=CC(C(C(O)=O)=C3)=O)C4=C1
Molecular Formula
C26H31F3N2O8
Molecular Weight
556.53
References & Citations
[1]Evangelos Aktoudianakis, et al. Compounds for the treatment of hepatitis b virus infection.WO2018144605A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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