Dual AChE-MAO B-IN-2

Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC50s of 0.12 μM and 0.01 μM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease[1].

Product Specifications

CAS Number

[1801157-64-1]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dual-ache-mao-b-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=C(C(CO)=C1)C=CC(OCC3=CC=C(CN(CC4=CC=CC=C4)C)C=C3)=C2

Molecular Formula

C26H25NO4

Molecular Weight

415.48

References & Citations

[1]Ekström F, et al. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. ACS Med Chem Lett. 2022, 13 (3) :499-506.