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A2A/A1 AR antagonist-1

A2A/A1 AR antagonist-1 (compound 1a) is dual potent A2A/A1 AR antagonist with Kis of 5.58 and 24.2 nM, respectively. A2A/A1 AR antagonist-1 has the potential for the research of ischemic stroke[1].

Product Specifications

CAS Number

2445615-24-5

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a2a-a1-ar-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC(C2=CN=C(N3N=C(C4=CC=CO4)N=C23)N)=CN1C

Molecular Formula

C15H12N6O2

Molecular Weight

308.29

References & Citations

[1]Tang ML, et al. Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Med Chem Lett. 2022;13 (3) :436-442. Published 2022 Feb 21.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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