A2A/A1 AR antagonist-1
A2A/A1 AR antagonist-1 (compound 1a) is dual potent A2A/A1 AR antagonist with Kis of 5.58 and 24.2 nM, respectively. A2A/A1 AR antagonist-1 has the potential for the research of ischemic stroke[1].
Product Specifications
CAS Number
2445615-24-5
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a2a-a1-ar-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CC(C2=CN=C(N3N=C(C4=CC=CO4)N=C23)N)=CN1C
Molecular Formula
C15H12N6O2
Molecular Weight
308.29
References & Citations
[1]Tang ML, et al. Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Med Chem Lett. 2022;13 (3) :436-442. Published 2022 Feb 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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