Pencitabine
Pencitabine (Pen) is an orally active anticancer agent. Pencitabine interferes with DNA synthesis and function by inhibiting multiple nucleotide-metabolizing enzymes and by misincorporation into DNA[1].
Product Specifications
CAS Number
[2249843-29-4]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pencitabine.html
Solubility
10 mM in DMSO
Smiles
FC1([C@H](N2C(N=C(C(F)=C2)NC(OCCCCC)=O)=O)O[C@@H]([C@H]1O)CO)F
Molecular Formula
C15H20F3N3O6
Molecular Weight
395.33
References & Citations
[1]Kalman TI. Rational Design of an Orally Active Anticancer Fluoropyrimidine, Pencitabine, a Hybrid of Capecitabine and Gemcitabine. ACS Med Chem Lett. 2022 Feb 21;13 (3) :409-416.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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