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MEK1/2-IN-2

MEK1/2-IN-2 is a potent ATP-competitive MEK1/2 inhibitor and shows equipotent inhibition of WT MEK1/2 and a panel of MEK1/2 mutant cell lines[1].

Product Specifications

UNSPSC

12352005

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mek1-2-in-2.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(OC2=CC=CC=N2)=CC=C1C3=C(F)C=C(N=CC4=C5N(C6CCN(CC#N)CC6)C=N4)C5=C3

Molecular Formula

C28H22ClFN6O

Molecular Weight

512.97

References & Citations

[1]Ramulu Poddutoori, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022 Mar 10;65 (5) :4350-4366.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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