MEK1/2-IN-2
MEK1/2-IN-2 is a potent ATP-competitive MEK1/2 inhibitor and shows equipotent inhibition of WT MEK1/2 and a panel of MEK1/2 mutant cell lines[1].
Product Specifications
UNSPSC
12352005
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mek1-2-in-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(OC2=CC=CC=N2)=CC=C1C3=C(F)C=C(N=CC4=C5N(C6CCN(CC#N)CC6)C=N4)C5=C3
Molecular Formula
C28H22ClFN6O
Molecular Weight
512.97
References & Citations
[1]Ramulu Poddutoori, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022 Mar 10;65 (5) :4350-4366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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