UCSF678
UCSF678 is a 42 nM arrestin-biased partial agonist at the 5-HT5AR with a more restricted off-target profile and decreased assay liabilities. UCSF678 is a selective probe with which to study the function of the 5-HT5AR[1].
Product Specifications
CAS Number
2361697-55-2
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ucsf678.html
Solubility
10 mM in DMSO
Smiles
O=S(C)(C1(CC1)CNCC2=CC=CC3=CC=CN=C32)=O
Molecular Formula
C15H18N2O2S
Molecular Weight
290.38
References & Citations
[1]Levit Kaplan A, et al. Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor. J Med Chem. 2022;65 (5) :4201-4217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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