CDK5-IN-2

CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].

Product Specifications

CAS Number

[2639542-22-4]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cdk5-in-2.html

Solubility

10 mM in DMSO

Smiles

FC1=CC(C2=CC=CC(C#N)=C2)=CC=C1NC3=CC4=NC([C@](C)(O)C5CCN(C)CC5)=CC=C4C=N3

Molecular Formula

C29H28FN5O

Molecular Weight

481.56

References & Citations

[1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65 (4) :3575-3596.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK2; CDK5

Curated Selection

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