HP1328
HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation) . HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].
Product Specifications
CAS Number
2245074-20-6
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hp1328.html
Solubility
10 mM in DMSO
Smiles
OCCOC1=CC=C(CNC2=CC(N=CN3C4=CC=CC=C4)=C3C=C2)C=C1OC
Molecular Formula
C23H23N3O3
Molecular Weight
389.45
References & Citations
[1]Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65 (4) :3597-3605.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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