HDAC-IN-33

HDAC-IN-33 is a potent HDAC inhibitor with IC50s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity[1].

Product Specifications

CAS Number

[2766688-19-9]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-33.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)CCCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1

Molecular Formula

C21H25N3O3

Molecular Weight

367.44

References & Citations

[1]"Chen C, et al. Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. J Med Chem. 2022 Feb 24;65 (4) :3667-3683. "