HDAC-IN-33
Product Specifications
UNSPSC Description
HDAC-IN-33 is a potent HDAC inhibitor with IC50s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-33.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)CCCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1
Molecular Weight
367.44
References & Citations
[1]"Chen C, et al. Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. J Med Chem. 2022 Feb 24;65(4):3667-3683.
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Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145688/HDAC-IN-33-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145688/
Clinical Information
No Development Reported
CAS Number
2766688-19-9
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