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HDP 30.1699

HDP 30.1699, the derivative of α-Amanitin, shows considerable cross-links. The cysteine residues of the anti-HER2 THIOMAB antibody are used for conjugation of the cysteine reactive linker–Amanitin compound, HDP 30.1699, with a cleavable linker by maleimide chemistry[1][2].

Product Specifications

CAS Number

[2004724-36-9]

UNSPSC

12352005

Target

ADC Payload; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdp-30-1699.html

Purity

99.13

Solubility

10 mM in DMSO

Smiles

O=C([C@]([H])([C@H](C)[C@H](O)CO)NC([C@@]1([H])N(C[C@H](O)C1)C([C@](CC(N)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC2=O)=O)=O)=O)([H])CO3=S)=O)=O)=O)N[C@]2([H])CC4=C3NC5=CC(OCC6=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C54

Molecular Formula

C61H80N14O19S

Molecular Weight

1345.44

References & Citations

[1]Torsten HECHLER, et al. Amanitin antibody conjugates. WO2018115466A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-145674/HDP-30-1699-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-145674/HDP-30-1699-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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