HDP 30.1699
Product Specifications
UNSPSC Description
HDP 30.1699, the derivative of α-Amanitin, shows considerable cross-links. The cysteine residues of the anti-HER2 THIOMAB antibody are used for conjugation of the cysteine reactive linker–Amanitin compound, HDP 30.1699, with a cleavable linker by maleimide chemistry[1][2].
Target Antigen
ADC Cytotoxin; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdp-30-1699.html
Purity
99.13
Solubility
10 mM in DMSO
Smiles
O=C([C@]([H])([C@H](C)[C@H](O)CO)NC([C@@]1([H])N(C[C@H](O)C1)C([C@](CC(N)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC2=O)=O)=O)=O)([H])CO3=S)=O)=O)=O)N[C@]2([H])CC4=C3NC5=CC(OCC6=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C54
Molecular Weight
1345.44
References & Citations
[1]Torsten HECHLER, et al. Amanitin antibody conjugates. WO2018115466A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145674/HDP-30-1699-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145674/HDP-30-1699-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2004724-36-9
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