Cis, trans-Germacrone
Cis, trans-Germacrone is a isomer of Germacrone (HY-N0440) . Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].
Product Specifications
CAS Number
[32663-51-7]
UNSPSC
12352211
Target
Akt; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-trans-germacrone.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O
Molecular Formula
C15H22O
Molecular Weight
218.33
References & Citations
[1]Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23 (6) :452.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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