Donepezil-d7 (hydrochloride)

Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

Product Specifications

CAS Number

[1261394-20-0]

Product Name Alternative

E2020-d7

UNSPSC

12352005

Hazard Statement

H301-H361-H372

Target

Cholinesterase (ChE) ; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)C([2H])([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H].Cl

Molecular Formula

C24H23D7ClNO3

Molecular Weight

423.00

Precautions

P260-P264-P280-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.; Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38 (1) : p. 181-93.; Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18 (2) : p. 185-7.