HS- (CH2) 3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S- (CH2) 5-CO-DM
HS- (CH2) 3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S- (CH2) 5-CO-DM is a agent-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety[1].
Product Specifications
CAS Number
2243689-64-5
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hs-ch2-3co-l-ala-d-ala-l-ala-nh-ch2-s-ch2-5-co-dm.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCSCNC([C@H](C)NC([C@@H](C)NC([C@H](C)NC(CCCS)=O)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Molecular Formula
C52H78ClN7O14S2
Molecular Weight
1124.80
References & Citations
[1]Costoplus JA, et al. Peptide-Cleavable Self-immolative Maytansinoid Antibody-Drug Conjugates Designed To Provide Improved Bystander Killing. ACS Med Chem Lett. 2019;10 (10) :1393-1399. Published 2019 Sep 27.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids
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