HS- (CH2) 3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S- (CH2) 5-CO-DM

HS- (CH2) 3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S- (CH2) 5-CO-DM is a agent-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety[1].

Product Specifications

CAS Number

[2243689-64-5]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hs-ch2-3co-l-ala-d-ala-l-ala-nh-ch2-s-ch2-5-co-dm.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCSCNC([C@H](C)NC([C@@H](C)NC([C@H](C)NC(CCCS)=O)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

Molecular Formula

C52H78ClN7O14S2

Molecular Weight

1124.80

References & Citations

[1]Costoplus JA, et al. Peptide-Cleavable Self-immolative Maytansinoid Antibody-Drug Conjugates Designed To Provide Improved Bystander Killing. ACS Med Chem Lett. 2019;10 (10) :1393-1399. Published 2019 Sep 27.