(R, R) -Reboxetine (mesylate)

(R, R) -Reboxetine mesylate is an antidepressant agent with great bioavailability. (R, R) -Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R, R) and (S, S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals[1][2].

Product Specifications

CAS Number

[105017-39-8]

Product Name Alternative

(R, R) -FCE20124 (mesylate) ; (R, R) -PNU155950E (mesylate) ; (R, R) - (-) -Reboxetine (mesylate)

UNSPSC

12352005

Target

Adrenergic Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-r-reboxetine-mesylate.html

Solubility

10 mM in DMSO

Smiles

CCOC1=CC=CC=C1O[C@@H]([C@@]2([H])CNCCO2)C3=CC=CC=C3.CS(=O)(O)=O

Molecular Formula

C20H27NO6S

Molecular Weight

409.50

References & Citations

[1]Wienkers LC, et al. Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. Drug Metab Dispos. 1999 Nov;27 (11) :1334-40. |[2]Dostert P, et al. Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor. Eur Neuropsychopharmacol. 1997 Apr;7 Suppl 1:S23-35; discussion S71-3.