Cemdomespib

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response[1][2][3].

Product Specifications

CAS Number

[1450642-92-8]

Product Name Alternative

KU-596

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cemdomespib.html

Solubility

10 mM in DMSO

Smiles

CC(NCCC1=C(C2=CC(F)=CC=C2)C=C(C=C1)O[C@H]3[C@@H]([C@@H]([C@H](C(C)(O3)C)OC)O)O)=O

Molecular Formula

C24H30FNO6

Molecular Weight

447.50

References & Citations

[1]Jiacheng Ma, et al. Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons. ACS Chem Neurosci. 2015 Sep 16;6 (9) :1637-48.|[2]Xinyue Zhang, et al. Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy. ACS Chem Neurosci. 2018 Feb 21;9 (2) :381-390.|[3]Zheng Zhang, et al. Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity. Bioorg Med Chem Lett. 2018 Sep 1;28 (16) :2701-2704.