GEM–IB
GEM–IB is the conjugate of gemcitabine (GEM) -5'-phosphate with ibandronate (IB) . GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS) [1].
Product Specifications
CAS Number
2866211-93-8
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gem-ib.html
Solubility
10 mM in DMSO
Smiles
CCCCCN(CCC(P(O)(O)=O)(P(O)(OP(O)(OC[C@H]1O[C@H](C(F)([C@@H]1O)F)N2C=CC(N)=NC2=O)=O)=O)O)C
Molecular Formula
C18H33F2N4O13P3
Molecular Weight
644.39
References & Citations
[1]Farrell KB, et al. Gemcitabine-Ibandronate Conjugate Enables the Bone-Targeted Combination Therapy in Bone Cancer: Synthesis and Efficacy in Combination with Docetaxel. Bioconjug Chem.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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