PI3K-IN-28
PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents[1].
Product Specifications
CAS Number
2747100-02-1
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-28.html
Solubility
10 mM in DMSO
Smiles
O=S(OC1=CC=C(C=C1)/C=N/N=C2SC=C(N\2C3=CC=CC=C3)C4=CC=CC=C4)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)=O
Molecular Formula
C26H16F9N3O3S2
Molecular Weight
653.54
References & Citations
[1]Tantawy AH, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites. J Med Chem. 2021 Dec 9;64 (23) :17468-17485.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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