Ziprasidone (mesylate trihydrate)

Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM) [1].

Product Specifications

CAS Number

[199191-69-0]

Product Name Alternative

CP-88059 (mesylate trihydrate)

UNSPSC

12352005

Hazard Statement

H317-H373

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ziprasidone-mesylate-trihydrate.html

Solubility

10 mM in DMSO

Smiles

O=S(C)(O)=O.ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.O.O.O

Molecular Formula

C22H31ClN4O7S2

Molecular Weight

563.09

Precautions

P260-P261-P272-P280-P302+P352-P362+P364-P501

References & Citations

[1]H Rollema, et al. 5-HT (1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000 Aug 1;48 (3) :229-37.|[2]Zhi Su, et al. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. Biochem Pharmacol. 2006 Jan 12;71 (3) :278-86.|[3]Subin Park, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012 Jun;61 (6) :787-93.