BT-GSI
BT-GSI is a γ-secretase inhibitor (GSI) and a bone-targeted Notch inhibitor. BT-GSI has dual anti-myeloma and anti-resorptive properties, which can be used for the research of multiple myeloma and associated bone disease. BT-GSI inhibits tumor growth and osteolytic disease progression[1].
Product Specifications
UNSPSC
12352005
Target
Notch; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bt-gsi.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)C(P(O)(O)=O)NC(CCCN(C)/N=C/[C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O.Br
Molecular Formula
C26H46BrN5O10P2
Molecular Weight
730.52
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145428/BT-GSI-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145428/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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