KIRA9
KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells) . KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis[1].
Product Specifications
CAS Number
2922507-65-9
UNSPSC
12352005
Target
Apoptosis; IRE1
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/kira9.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O
Molecular Formula
C27H27F3N6O3S
Molecular Weight
572.60
References & Citations
[1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021;17 (11) :1148-1156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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