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IRE1α kinase-IN-4

IRE1α kinase-IN-4 (compound 6) is a potent IRE1α inhibitor with an Ki of 140 nM. IRE1α kinase-IN-4 is the ATP-competitive ligands of IRE1α[1].

Product Specifications

CAS Number

2771006-45-0

UNSPSC

12352005

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ire1α-kinase-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1CC1)NC(C2=C3C=CC=C2)=CC=C3OC4=NC=CC=C4C5=NC(N[C@H]6CC[C@H](N)CC6)=NC=C5

Molecular Formula

C29H31N7O2

Molecular Weight

509.60

References & Citations

[1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17 (11) :1148-1156.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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