IRE1α kinase-IN-4
IRE1α kinase-IN-4 (compound 6) is a potent IRE1α inhibitor with an Ki of 140 nM. IRE1α kinase-IN-4 is the ATP-competitive ligands of IRE1α[1].
Product Specifications
CAS Number
2771006-45-0
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC1)NC(C2=C3C=CC=C2)=CC=C3OC4=NC=CC=C4C5=NC(N[C@H]6CC[C@H](N)CC6)=NC=C5
Molecular Formula
C29H31N7O2
Molecular Weight
509.60
References & Citations
[1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17 (11) :1148-1156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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