IRE1α kinase-IN-3
IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α[1].
Product Specifications
CAS Number
2416223-41-9
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC=CC2=C1C=CC=C2OC3=C(C4=NC(N[C@H]5CC[C@@H](CC5)N)=NC=C4)C=CC=N3)(C6CCC6)=O
Molecular Formula
C29H32N6O3S
Molecular Weight
544.67
References & Citations
[1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17 (11) :1148-1156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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