G247
G247 is a specific MsbA inhibitor. G247 acts as a transmembrane domains (TMDs) wedge, symmetrically increasing nucleotide-binding domains (NBDs) separation and preventing conformational transition of MsbA. G247 suppresses ATPase activity by increasing inter-NBD distance[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/g247.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=C(C=CC(F)=C1Cl)Cl)OC2=CC3=C(C=CC(/C=C/C(O)=O)=C3C4CC4)C=C2
Molecular Formula
C24H19Cl2FO3
Molecular Weight
445.31
References & Citations
[1]Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M. Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science. 2021;374 (6567) :580-585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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