CDK7/9-IN-1
CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].
Product Specifications
CAS Number
[2747919-19-1]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk7-9-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CN=C2N1C=C(C(F)(F)F)C=C2NC3CCN(CC3)C[C@@H]4CN(CCO4)C(C=C)=O)C
Molecular Formula
C24H32F3N5O2
Molecular Weight
479.54
References & Citations
[1]Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK7; CDK9
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