DGN549-L
Product Specifications
UNSPSC Description
DGN549-L is a DNA alkylator and can be utilized for antibody conjugation at lysine residues. DGN549-L can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target Antigen
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dgn549-l.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2)N3C4=CC=CC=C4C[C@@]3([H])CNC1=CC(OCC5=CC(COC(C=C(N=C[C@@]6([H])N(C7=CC=CC=C7C6)C8=O)C8=C9)=C9OC)=CC(NC([C@H](C)NC([C@H](C)NC(CCCCC(ON(C%10=O)C(CC%10)=O)=O)=O)=O)=O)=C5)=C2OC
Molecular Weight
1075.13
References & Citations
[1]Bai C, et al. Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation. Bioconjug Chem. 2020;31(1):93-103.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145365/DGN549-L-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145365/
Clinical Information
No Development Reported
CAS Number
1884276-68-9
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