DGN549-L

DGN549-L is a DNA alkylator and can be utilized for antibody conjugation at lysine residues. DGN549-L can be used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[1884276-68-9]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dgn549-l.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2)N3C4=CC=CC=C4C[C@@]3([H])CNC1=CC(OCC5=CC(COC(C=C(N=C[C@@]6([H])N(C7=CC=CC=C7C6)C8=O)C8=C9)=C9OC)=CC(NC([C@H](C)NC([C@H](C)NC(CCCCC(ON(C%10=O)C(CC%10)=O)=O)=O)=O)=O)=C5)=C2OC

Molecular Formula

C58H58N8O13

Molecular Weight

1075.13

References & Citations

[1]Bai C, et al. Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation. Bioconjug Chem. 2020;31 (1) :93-103.