SGLT1/2-IN-2
SGLT1/2-IN-2 demonstrates potent dual inhibitory activities (IC50 = 96 nM for SGLT1 and IC50 = 1.3 nM for SGLT2) .
Product Specifications
CAS Number
2387812-73-7
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sglt1-2-in-2.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](C2=CC(CC3=CC=C(OCCC4)C4=C3)=C(C=C2O)OC)O[C@@H](C(F)([C@@H]1O)F)CO
Molecular Formula
C23H26F2O7
Molecular Weight
452.45
References & Citations
[1]Xu G, et al. 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors. Bioorg Med Chem Lett. 2020 Sep 1;30 (17) :127387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT1; SGLT2
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