HTL22562
HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute research of migraine.
Product Specifications
CAS Number
2097085-63-5
UNSPSC
12352005
Target
CGRP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/htl22562.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2(OC(NC3=NC=CC=C32)=O)CC1)N[C@H](CC4=CC5=C(NN=C5)C(C)=C4)C(N[C@@H](CC6CCNCC6)C(N7CCN(C8=CC=NC=C8)CC7)=O)=O
Molecular Formula
C40H49N11O5
Molecular Weight
763.89
References & Citations
[1]Bucknell SJ, et al. Structure-Based Drug Discovery of N- ((R) -3- (7-Methyl-1H-indazol-5-yl) -1-oxo-1- (((S) -1-oxo-3- (piperidin-4-yl) -1- (4- (pyridin-4-yl) piperazin-1-yl) propan-2-yl) amino) propan-2-yl) -2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562) : A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine. J Med Chem. 2020 Jul 23;63 (14) :7906-7920.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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