FXIa-IN-6
FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (Ki = 0.3 nM) .
Product Specifications
CAS Number
1551459-37-0
UNSPSC
12352005
Target
Factor Xa
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fxia-in-6.html
Solubility
10 mM in DMSO
Smiles
COC(NC1=CC=C(C2=CC=NC([C@](N3C(C=C(C4=C(C(Cl)=CC=C4F)F)CC3)=O)([H])CCC[C@H](C(N5)=O)C)=C2)C5=C1)=O
Molecular Formula
C31H29ClF2N4O4
Molecular Weight
595.04
References & Citations
[1]Yang W, et al. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. J Med Chem. 2020 Jul 9;63 (13) :7226-7242.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
