2'-O-Propargyl A (Bz) -3'-phosphoramidite
2'-O-Propargyl A (Bz) -3'-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. 2'-O-Propargyl A (Bz) -3'-phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[171486-59-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-o-propargyl-a-bz-3-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
C#CCO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)O[C@H]1N5C=NC6=C5N=CN=C6NC(C7=CC=CC=C7)=O
Molecular Formula
C50H54N7O8P
Molecular Weight
911.98
Precautions
H302, H315, H319
References & Citations
[1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26 (6) :1490-1500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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