ARG1-IN-1
ARG1-IN-1 (example 1) is a human arginase 1 inhibitor with an IC50 of 29 nM[1].
Product Specifications
CAS Number
[2376189-62-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arg1-in-1.html
Solubility
10 mM in DMSO
Smiles
OB(O)CCC[C@H]1[C@@]2([H])[C@@](CNC2)([H])C[C@@]1(N)C(O)=O
Molecular Formula
C11H21BN2O4
Molecular Weight
256.11
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Mitcheltree MJ, et al. Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Med Chem Lett. 2020 Mar 23;11 (4) :582-588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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