PARP-1/2-IN-1
PARP-1/2-IN-1 is a potent PARP-1/2 inhibitor with IC50 of 0.51 nM and 23.11 nM, respectively.
Product Specifications
CAS Number
1903744-45-5
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/parp-1-2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=O)C2=CC=CC=C2N1CC3=CC(C(N4C[C@H](N(CC4)CC)CC)=O)=C(C=C3)F
Molecular Formula
C24H27FN4O3
Molecular Weight
438.49
References & Citations
[1]Zhou J, et al. Discovery of Quinazoline-2,4 (1H,3H) -dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2021 Nov 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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