Antimalarial agent 7

Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum[1].

Product Specifications

CAS Number

2756414-77-2

UNSPSC

12352005

Target

Na+/K+ ATPase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-7.html

Solubility

10 mM in DMSO

Smiles

CC(C)(OC1=CC=C(C=C1)C2=NN=C3C=NC=C(N32)OCC(C4=CC(F)=C(C=C4)F)O)C

Molecular Formula

C23H22F2N4O3

Molecular Weight

440.44

References & Citations

[1]Tse EG, et al. An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials. J Med Chem. 2021;64 (22) :16450-16463.