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LRRK2-IN-3

LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].

Product Specifications

CAS Number

[2641054-60-4]

UNSPSC

12352005

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lrrk2-in-3.html

Solubility

10 mM in DMSO

Smiles

FC1([C@@](N2C(C)=C(C=N2)NC3=NC4=C(C=C(C(C5CCN([C@]6([C@H](COC6)O)C)CC5)=C4)Cl)C=N3)([H])C1)F

Molecular Formula

C25H29ClF2N6O2

Molecular Weight

518.99

References & Citations

[1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65 (1) :838-856.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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